Brain imaging: assessing therapy responses using quantitative imaging biomarkers

摘要: Abstract: Neuroimaging is essential for both the diagnosis and evaluation of therapeutic response intracranial tumors. Measurement structural changes in tumor morphology after institution therapy using magnetic resonance imaging (MRI) serves as current gold standard monitoring response; however, information prognostic value cannot be obtained until weeks initiation treatment. Positron emission tomography (PET) radiolabled ligands that trace physiologic processes offers promise a method early assessment, although to date neuro-oncologic utility PET has not been good enough replace standard. This chapter first reviews some methods which MR used evaluate environment (e.g. spectroscopy diffusion-weighted imaging). The then surveys several tracers are either currently clinical use FDG) or under investigation FLT) discusses their assessment.