Dissemination and Activity of AL 721 after Oral Administration

摘要: Absorption of phospholipids in the small intestine is, general, associated with hydrolysis by pancreatic lipases to water soluble products that eventualy reintegrate mucosa cells. An alternative route phospholipid absorption is endocytosis and tight assemblies like liposomes without hydrolysis. It might be therefore expected shortly after through one these routes their composition blood stream largely preserved. Along this rationale AL 721, a lipid mixture designated reduce excess cholesterol from peripheral membranes, can administered per os for vivo application. A series animal human studies, where 721 was os, lend support conclusion.