Melatonin as a promising agent of regulating stem cell biology and its application in disease therapy
作者： Shuo Zhang , Simon Chen , Yuan Li , Yu Liu
DOI: 10.1016/J.PHRS.2016.12.035
关键词:
摘要: Stem cells have emerged as an important approach to repair and regenerate damaged tissues or organs show great therapeutic potential in a variety of diseases. However, the low survival engrafted stem still remains major challenge for cell therapy. As hormone from pineal gland, melatonin has been shown play role regulating physiological pathological functions cells, such promoting proliferation, migration differentiation. Thus, combined with transplantation displayed promising application neurodegenerative diseases, liver cirrhosis, wound healing, myocardial infarction, kidney ischemia injury, osteoporosis, etc. It exerts its through anti-oxidant, anti-inflammatory, anti-apoptosis anti-ageing properties. Here, we summarize recent advances on exploring biological discuss applications cell-based
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