Oxidative Stress in the Kidney: Proximal Tubule Disorders

摘要: Redox changes initiate various cellular signals in the cells, and redox environment can determine if a cell will proliferate, differentiate, or die. Imbalance of status such as during oxidative stress trigger series events, leading to dysfunction. Reactive oxygen species (ROS) are increasingly considered being involved initiation progression chronic renal disease. The proximal tubule is major site ROS production, due its high transport activity supported by an consuming metabolism. Various congenital acquired disorders induce cells (PTC), which characterized their capacity for receptor-mediated endocytosis albumin. Recent studies suggest that albumin exerts dual effect on tubule. In physiological conditions, survival factor, protecting against oxidant injury. case glomerular proteinuria, exposure PTC excess induces causes Furthermore, defects endocytic uptake also related state increased stress, causing tubulointerstitial fibrosis failure. this chapter, we review available evidence about nature stimuli initial events generation antioxidant mechanisms PTC.