DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
作者： Jan van Oostrum , Bernd Meyhack , Jutta Heim , Sefik Alkan , Fredericus A. M. Asselbergs
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摘要: Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in identity and number to human t-PA u-PA, mutants thereof which one the N-glycosylation sites is modified such that glycosylation cannot take place these exhibit valuable pharmacological properties. The are produced by recombinant DNA technology.
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