Abemaciclib: A multi-functional radiation modifier.

Holly E. Barker, James T. E. Paget, Aadil A. Khan, Kevin J. Harrington, The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence Nature Reviews Cancer. ,vol. 15, pp. 409- 425 ,(2015) , 10.1038/NRC3958

Mitomu Kioi, Hannes Vogel, Geoffrey Schultz, Robert M. Hoffman, Griffith R. Harsh, J. Martin Brown, Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice Journal of Clinical Investigation. ,vol. 120, pp. 694- 705 ,(2010) , 10.1172/JCI40283

Smruthi Vijayaraghavan, Cansu Karakas, Iman Doostan, Xian Chen, Tuyen Bui, Min Yi, Akshara S. Raghavendra, Yang Zhao, Sami I. Bashour, Nuhad K. Ibrahim, Meghan Karuturi, Jing Wang, Jeffrey D. Winkler, Ravi K. Amaravadi, Kelly K. Hunt, Debu Tripathy, Khandan Keyomarsi, CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers. Nature Communications. ,vol. 8, pp. 15916- 15916 ,(2017) , 10.1038/NCOMMS15916

Hiroji Iwata, Clinical development of CDK4/6 inhibitor for breast cancer Breast Cancer. ,vol. 25, pp. 402- 406 ,(2018) , 10.1007/S12282-017-0827-3

Mary E. Klein, Marta Kovatcheva, Lara E. Davis, William D. Tap, Andrew Koff, CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought. Cancer Cell. ,vol. 34, pp. 9- 20 ,(2018) , 10.1016/J.CCELL.2018.03.023

Sarwat Naz, Anastasia Sowers, Rajani Choudhuri, Maria Wissler, Janet Gamson, Askale Mathias, John A. Cook, James B. Mitchell, Abemaciclib, a Selective CDK4/6 Inhibitor, Enhances the Radiosensitivity of Non–Small Cell Lung Cancer In Vitro and In Vivo Clinical Cancer Research. ,vol. 24, pp. 3994- 4005 ,(2018) , 10.1158/1078-0432.CCR-17-3575

Eric C. Ko, David Raben, Silvia C. Formenti, The Integration of Radiotherapy with Immunotherapy for the Treatment of Non–Small Cell Lung Cancer Clinical Cancer Research. ,vol. 24, pp. 5792- 5806 ,(2018) , 10.1158/1078-0432.CCR-17-3620

Malaka Ameratunga, Emma Kipps, Alicia F.C. Okines, Juanita S. Lopez, To Cycle or Fight—CDK4/6 Inhibitors at the Crossroads of Anticancer Immunity Clinical Cancer Research. ,vol. 25, pp. 21- 28 ,(2019) , 10.1158/1078-0432.CCR-18-1999