Aberrant promoter methylation in genes related to hematopoietic malignancy in workers exposed to a VOC mixture
作者： Octavio Jiménez-Garza , Liqiong Guo , Hyang-Min Byun , Mariella Carrieri , Giovanni Battista Bartolucci
DOI: 10.1016/J.TAAP.2017.12.002
关键词:
摘要: Abstract Occupational exposure to volatile organic compounds (VOCs) may cause hematopoietic malignancy, either by single benzene or possibly due a concomitant several VOCs. Since oxidative stress, inflammation and DNA repair pathways are closely involved in cancer development, the effect of VOC on expression proteins these has been studied, but epigenetic changes have not well described. Here, methylation status following occupational mixture was assessed bisulfite sequencing promoter regions seven genes mentioned pathways. Peripheral blood samples individual-level data were obtained from healthy leather shoe factory workers (LS, n = 40) gas station attendants (GS, n = 36), as reference group university employees (C, n = 66). Exposure levels for acetone, ethylbenzene, methyl ethyl ketone, n-hexane, toluene xylene higher LS (p
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