Concise synthesis of didebromohamacanthin A and demethylaplysinopsine: addition of ethylenediamine and guanidine derivatives to the pyrrole-amino acid diketopiperazines in oxidative conditions.
作者： Ludmila Ermolenko , Hu Zhaoyu , Clarisse Lejeune , Carine Vergne , Céline Ratinaud
DOI: 10.1021/OL4036177
关键词:
摘要: Oxidative nucleophilic addition of ethylenediamine and guanidine derivatives to pyrrole-amino acid diketopiperazines was shown provide substituted 5,6-dihydro-2(1H)-piperazinones, quinoxalinones, 2-aminoimidazolones. On the basis this methodology, a concise approach natural products didebromohamacanthin A demethylaplysinopsine has been demonstrated.
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