Exploring the inhibitory mechanism of piceatannol on α-glucosidase relevant to diabetes mellitus
作者： Lili Jiang , Zhen Wang , Xiaoyu Wang , Shujuan Wang , Jun Cao
DOI: 10.1039/C9RA09028B
关键词:
摘要: Due to their association with type 2 diabetes mellitus treatment, α-glucosidase inhibitors have attracted increasing attention of researchers. In this study, we systemically investigated the kinetics and inhibition mechanism piceatannol on α-glucosidase. Enzyme analyses showed that exhibited strong in a non-competitive manner. Spectroscopy indicated could bind form complexes via high affinity. Further, computational molecular dynamics docking studies validated binding was outside catalytic site α-glucosidase, which would induce conformational changes block entrance substrate, causing declines activities. Our results provide useful information not only for against but also novel target developing as potential therapeutic agents treatment mellitus.
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