Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms-The Risk of Malignant Tumors and Other Diseases.
作者： Dominika Rozmus , Alicja Ciesielska , Janusz Płomiński , Roman Grzybowski , Ewa Fiedorowicz
DOI: 10.3390/IJMS21217822
关键词:
摘要: Vitamin D is an important component of the endocrine system that controls calcium homeostasis and bone mineralization. Because very short half-life free serum vitamin it stabilized transported to target tissues by being bound binding protein (VDBP). The most common polymorphisms: rs4588 rs7041 in gene may correlate with differences status serum. This review presents data relate presence genetic variants VDBP correlation certain diseases, mostly concerning cancers (breast, prostate, pancreatic, lung, colorectal, basal cell carcinoma cancer cutaneous melanoma) or other related diseases (thyroid autoimmunity disorders, obesity, diabetes mellitus, metabolism, rheumatoid arthritis, ankylosing spondylitis, asthma, chronic obstructive pulmonary disease, tuberculosis coronary artery diseases).
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