Polymorphisms in Toll-Like Receptor 10 and Tuberculosis Susceptibility: Evidence from Three Independent Series

摘要: Background: The toll-like receptor 2 (TLR2) mediated immune response is critical for host defense against Mycobacterium tuberculosis. There evidence that TLR10, a TLR2 signaling modulator, may be involved in progression of tuberculosis (TB). Methods: Using self-validating case–control design, we tested an association between seven TLR10 polymorphisms and susceptibility to TB three independent series with two distinct populations. Single nucleotide polymorphism (SNP) genotypes were determined by the SNPscanTM method. Three genetic models (additive, dominant, recessive) as well multiple-SNP score analyses used evaluate risk associated SNPs. Results: By comparing patients healthy controls, observed SNPs (rs11466617 rs4129009) decreased Tibetan population, but did not Chinese Han population. Further analysis demonstrated rs11466617 CC genotype served protective factor latent infection (LTBI) active under recessive model. None significantly different comparisons uninfected people LTBI individuals. Additionally, when underlying four TB-associated loci considered together analysis, allele dose-dependent decrease Tibetans. Conclusion: Variants show ethnic specificity on affected progress from disease, was establishment after exposure. More studies are needed verify this epidemiological result unravel role pathogenesis TB.