Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice.

摘要: Serotonin (5-HT), via its receptors expressed in discrete brain regions, modulates aversion and reward processing is implicated various psychiatric disorders including depression. Stressful experiences affect central serotonergic activity act as a risk factor for depression; this can be modelled preclinically. In adult male C57BL/6J mice, 15-day chronic social stress (CSS) leads to depression-relevant behavioural states, increased reduced sensitivity. Based on evidence, here we investigated CSS effects 5-HT1A, 5-HT2A, 5-HT2C receptor binding regions using vitro quantitative autoradiography with selective radioligands. addition, mRNA expression of Htr1a, 2a, 2c Slc6a4 (5-HT transporter) was measured by PCR. Relative controls, the following were observed mice: 5-HT1A markedly dorsal raphe nucleus (136%); Htr1a nuclei (19%), medial prefrontal cortex (35%), hypothalamic para- periventricular (21%) ventral (38%). 5-HT2A decreased amygdala (48%) tegmental area (60%); Htr2a baso-lateral (116%). (42%). (59%). The present findings add translational evidence that impacts system region- receptor-specific manner, altered state contributes stress-induced dysfunctions emotional processing.