Molecular and Cellular Factors Determining Cell Susceptibility to Heat Shock

摘要: Although hyperthermia has long been applied as one of the methods used for cancer therapy, mechanisms responsible higher heat sensitivity human tumor cells have not yet elucidated completely. Studies shown that targets lethal effects involve only cytoskeletal proteins and extracellular matrix but also centrosomes, are deficient in repairing damage to these components. It is well known most normal arrest their cell cycle after treatment. Furthermore, it reported activation intracellular signal transduction mediators, such mitogen-activated protein (MAP) kinases, involved response hyperthermia, often detected cells. These novel findings provide a new insight into by which responsive hyperthermia. The role factors relation discussed.