Clinical Trials : A Methodologic Perspective

摘要: Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting trials with the goal improving evidence derived from these important studies This Third Edition builds on text s reputation as a straightforward, detailed, authoritative presentation quantitative for trials. Readers will encounter principles design various types trials, then skillfully guided through complete process planning experiment, assembling study cohort, assessing data, reporting results. Throughout process, author alerts readers to problems may arise during course provides common sense solutions. All stages therapeutic development discussed detail, not restricted single application area. The authors bases current revisions updates his own experience, classroom instruction, feedback teachers medical statistical professionals involved greatly expands its coverage, ranging new provocative topics, including alternative medicine ethics, middle development, comparative studies, adaptive designs. At same time, it offers more pragmatic advice issues such selecting outcomes, sample size, analysis, reporting, handling allegations misconduct. familiar First Second Editions discover revamped exercise sets; an updated extensive reference section; material endpoints developmental pipeline, among others; numerous sections. In addition, this book: Features accessible broad coverage crucial building blocks research -- now chapters overall designs Teaches produce valid qualitative results backed by rigorous Contains introduction summary each chapter reinforce key points Includes discussion questions stimulate critical thinking help understand how they can apply their newfound knowledge Provides references direct most recent literature, there or revised exercises throughout book Clinical Trials: A Methodologic Perspective, is textbook advanced undergraduate students sciences, graduate public health life physicians training methods, biostatisticians epidemiologists. Steven Piantadosi, MD, PhD, Phase One Foundation Distinguished Chair Director Samuel Oschin Cancer Institute, Professor Medicine at Cedars-Sinai Medical Center Los Angeles, California. Dr. Piantadosi one world leading experts analysis cancer research. He has taught extensively formal courses short venues. advised academic programs collaborations nationally regarding conduct, served external advisory boards National Institutes Health other prominent centers. than 260 peer-reviewed scientific articles, published results, applications, methodology. While papers have contributed many areas oncology, he also collaborated diverse outside oncology lung disease degenerative neurological disease.