Allergic contact dermatitis in the hamster and in other rodents.

摘要: The first, and for a long time the only, experimental animal study of allergic contact dermatitis (ACD) was guinea pig (1). Thus basic studies that related sensitization potential to ability low molecular weight allergen couple protein, established requirement viable lymphoid cells (not sera) passive transfer hypersensitivity simple chemical allergens, demonstrated induction specific immunological unresponsiveness were done in (2,3, 4,5). Indeed, still remains choice identification allergens man (6,7). In 1968, technique measuring increased ear thickness as way assessing induced inflammation by mouse introduced (8); contrast pig, inflammatory skin reactions on flank are difficult evaluate since these lack both erythema easily defined induration. recently has been extended hamster (9,10) we using same methodology ACD rats (11). This report examines relates it other species.