Continuous bed motion Vs. step-and-shoot acquisition on clinical whole-body dynamic and parametric PET imaging

摘要: Continuous bed motion (CBM) has been recently introduced in the clinic as an alternative PET acquisition mode with respect to traditional time-discretized step-and-shoot (SS) multi-bed acquisitions. In CBM mode, each slice can be considered a different bed, since it is scanned over window. By reducing scan time discretization from whole down single slice, offers additional degrees of freedom when designing protocols and thus larger margins for their optimization. Therefore, could particularly important higher complexity, such whole-body (WB) dynamic However, only few studies have quantitatively validated 2 modes on clinical data. this work, we evaluate vs. SS quantitative performance set data acquired 0–60min period using WB protocol Biograph mCT TOF scanner. The resolution (580ps) scanner allowed selecting faster speeds (4.2mm/sec) equivalent frames (30sec/bed), eventually permitting 12 total passes which half were performed mode. two alternated between successive allow balanced interleaving post-injection them ensure objective comparison. evaluation terms target-to-background (TBR) contrast contrast-to-noise ratio (CNR) conducted various noise levels by gradually adding all respective well parametric images after applying post-reconstruction Patlak analysis. Our results indicate bias ∼10% low count frames, <3% add frames. addition, small <10% was observed at overlapped slices beds, attributed non-uniformity axial sensitivity profile