Catalytic Asymmetric γ-Lactam Synthesis from Enolisable Anhydrides and Imines.
作者： Aarón Gutiérrez Collar , Cristina Trujillo , Bruce Lockett‐Walters , Brendan Twamley , Stephen J. Connon
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摘要: An anion-binding approach to the problem of preparing enantioenriched γ-lactams from enolisable anhydrides and imines is reported. A simple bisurea catalyst promotes cycloaddition between α-aryl succinic either PMP- or benzhydryl-protected aldimines provide with two contiguous stereocentres (one quaternary) complete diastereocontrol high excellent enantioselectivity for first time. DFT study has provided insight into mode action origins observed stereocontrol.
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