The Norepinephrine Analog Meta-Iodo-Benzylguanidine (MIBG) as a Substrate for Mono(ADP-Ribosylation)
作者： C. Loesberg , H. v. Rooij , L. A. Smets
DOI: 10.1007/978-3-642-74200-2_18
关键词:
摘要: Human tumors of neuro-ectodermal origin such as pheochromocytoma, neuroblastoma and medullary thyroidoma, have often preserved the capacity neuronal cells to recapture extracellular norepinephrine. Meta-iodo-benzylguanidine (MIBG; Wieland et al., 1980), is a functional analog norepinephrine, derived from neuron-blocking agents bretyllium guanethidine which competes with biogenic amines for uptake storage into chromaffin tissues. Radioiodinated [131I]- MIBG has been successfully applied scintigraphic visualization adrenergic tissues (Wieland 1981) neuroendocrine pheochromocytoma (Sisson 1981; Shapiro 1985), (Treuner 1984; Hoefnagel 1985) many other APUD series (Von Moll 1987). During clinical application [131I]-MIBG radiotherapeutic intent, patients receive milligram amounts potentially active amine. We therefore investigated pharmacological properties this novel radiopharmaceutical.
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