Drug specificity of pharmacological dystonia.

摘要: Three (+)-benzomorphans that bind to sigma receptors produced dystonia in a dose-related manner when microinjected into the red nucleus of rats. Two lines evidence suggest these effects were related sigma-binding properties compounds. First, behavioral potency and other active compounds correlated highly with their affinities for [3H]1,3-di-o-tolylguanidine-labelled rat brain (r = .94). Second, similar intrarubral injections non-sigma ligands without effect: various vehicles, structurally (+)-opiate no affinity receptors, selective dopaminergic serotonergic failed significantly alter normal posture The only ligand this study binds high but elicit torsional head movements was (+)-[3-(3-hydroxyphenyl)-N-(1-propyl)piperidine] [(+)-3PPP], mixed activity at dopamine receptors. Since (+)-3PPP produce an effect on its own also attenuate by another (DTG), it may interact mechanism or different receptor type from