Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteers

摘要: AbstractA putative haematotoxic and leukaemogenic metabolite of benzene, 1,4-benzoquinone (1,4-BQ), reacts rapidly with macromolecules. The authors previously characterized levels the albumin (Alb) adduct (1,4-BQ-Alb) this reactive species in populations workers exposed to benzene. Since high 1,4-BQ-Alb were also measured unexposed from those investigations, current study was initiated determine potential sources 1,4-BQ general population. A single blood sample collected 191 healthy subjects Research Triangle area, NC, USA, baseline contributing sources. median at 550 pmol g−1 Alb (interquartile range 435–814 pmol g−1). second approximately 3 months later a subgroup 33 estimate within- between-person variation 1,4-BQ-Alb. Standardized questionnaires administered collect information about demographic, dietary ...