Survival determinants in extensive-stage non-small-cell lung cancer: the Southwest Oncology Group experience.

摘要: We analyzed the 2,531-patient Southwest Oncology Group extensive-stage non-small-cell lung cancer (ENSCLC) data base from 1974 to 1988 (1) assess interactions of host- or tumor-related prognostic factors and therapy using Cox modeling recursive partitioning amalgamation (RPA) determine whether each independently predicts outcome, (2) use RPA define subsets with different survival potentials. Good performance status (PS), female sex, age greater than equal 70 years were significant independent predictors in a model applied entire population. In second for patients good PS enrolled on recent studies, hemoglobin level 11.0 g/dL, normal lactate dehydrogenase (LDH), calcium, single metastatic site favorable factors. The cisplatin was an additional predictor improved outcome both models after adjustments year accrual all variables. Th...