Self-Association of Insulin Reconsidered
作者： A. Wollmer , T. Mülders
关键词:
摘要: The self-association of insulin has been a challenge for half century. According to the crystal structure there are only two types contacts between subunits in hexamer, strong and weak one. This suggests that corresponding equilibrium constants should suffice describe association/dissociation behaviour solution.
springer.com
sci-hub.st 参考文章(28)
Tom Blundell, Guy Dodson, Dorothy Hodgkin, Dan Mercola, Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by Advances in Protein Chemistry. ,vol. 26, pp. 279- 402 ,(1972) , 10.1016/S0065-3233(08)60143-6
W Kadima, M Roy, R.W. Lee, N.C. Kaarsholm, M.F. Dunn, Studies of the association and conformational properties of metal-free insulin in alkaline sodium chloride solutions by one- and two-dimensional 1H NMR. Journal of Biological Chemistry. ,vol. 267, pp. 8963- 8970 ,(1992) , 10.1016/S0021-9258(19)50374-X
P. J. Hajduk, DRUG DESIGN: Discovering High-Affinity Ligands for Proteins Science. ,vol. 278, pp. 497- 499 ,(1997) , 10.1126/SCIENCE.278.5337.497
Tom Blundell, Chemistry, structure and function of insulin and related hormones : A report on the 2nd International Insulin Symposium, Aachen, Germany, 4–7 September 1979 FEBS Letters. ,vol. 109, pp. 167- 170 ,(1980) , 10.1016/0014-5793(80)81078-7
Alan E. Mark, Lawrence W. Nichol, Peter D. Jeffrey, The self-association of zinc-free bovine insulin Biophysical Chemistry. ,vol. 27, pp. 103- 117 ,(1987) , 10.1016/0301-4622(87)80051-0
S. B. Shuker, P. J. Hajduk, R. P. Meadows, S. W. Fesik, Discovering High-Affinity Ligands for Proteins: SAR by NMR Science. ,vol. 274, pp. 1531- 1534 ,(1996) , 10.1126/SCIENCE.274.5292.1531
Isaiah Pittman, Howard S. Tager, A spectroscopic investigation of the conformational dynamics of insulin in solution. Biochemistry. ,vol. 34, pp. 10578- 10590 ,(1995) , 10.1021/BI00033A033
A. Wollmer, J. Fleischhauer, W. Strassburger, H. Thiele, Side-chain mobility and the calculation of tyrosyl circular dichroism of proteins. Implications of a test with insulin and des-B1-phenylalanine insulin Biophysical Journal. ,vol. 20, pp. 233- 243 ,(1977) , 10.1016/S0006-3495(77)85546-X
Allen H. Pekar, Bruce H. Frank, Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH. Biochemistry. ,vol. 11, pp. 4013- 4016 ,(1972) , 10.1021/BI00772A001
Jose Goldman, Frederick H. Carpenter, Zinc binding, circular dichroism, and equilibrium sedimentation studies on insulin (bovine) and several of its derivatives. Biochemistry. ,vol. 13, pp. 4566- 4574 ,(1974) , 10.1021/BI00719A015