CD2-SLFA3/T11TS interaction facilitates immune activation and glioma regression by apoptosis.

作者: Susobhan Sarkar , Anirban Ghosh , Joydeep Mukherjee , Samares Chaudhuri , Swapna Chaudhuri

DOI: 10.4161/CBT.3.11.1214

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摘要: Objective: Exogenous application of T11TS/SLFA3 in glioma model had shown the regression tumor load through immunopotentiation. The mechanistic module this interaction on immunological synapse formation and resulting effect is searched for delineating immunotherapeutic efficacy T11TS. Methods: After purification from sheep erythrocytes glycoprotein was characterized by SDS-PAGE analysis staining. modulatory T11TS animals were studied CD2 MHC class II expression peripheral lymphocytes, PMN, macrophages intracranial microglia flowcytometric analysis. Finally apoptotic killing brain cells annevin-V measuring fragmented cytoplasmic DNA ELISA. Results: Compared to healthy normal counter-parts receptor downregulation ENU treatment lymphocytes PMN upregulated with three consecutive doses Splenic antigen presenting macroph...

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