Molecular genetics of ependymomas and pediatric diffuse gliomas: a short review

Ian F Pollack, Sydney D Finkelstein, Judith Burnham, Emiko J Holmes, Ronald L Hamilton, Allan J Yates, Jonathan L Finlay, Richard Sposto, Children’s Cancer Group, Age and TP53 Mutation Frequency in Childhood Malignant Gliomas: Results in a Multi-institutional Cohort Cancer Research. ,vol. 61, pp. 7404- 7407 ,(2001)

Matthew Parker, Kumarasamypet M Mohankumar, Chandanamali Punchihewa, Ricardo Weinlich, James D Dalton, Yongjin Li, Ryan Lee, Ruth G Tatevossian, Timothy N Phoenix, Radhika Thiruvenkatam, Elsie White, Bo Tang, Wilda Orisme, Kirti Gupta, Michael Rusch, Xiang Chen, Yuxin Li, Panduka Nagahawhatte, Erin Hedlund, David Finkelstein, Gang Wu, Sheila Shurtleff, John Easton, Kristy Boggs, Donald Yergeau, Bhavin Vadodaria, Heather L Mulder, Jared Becksfort, Pankaj Gupta, Robert Huether, Jing Ma, Guangchun Song, Amar Gajjar, Thomas Merchant, Frederick Boop, Amy A Smith, Li Ding, Charles Lu, Kerri Ochoa, David Zhao, Robert S Fulton, Lucinda L Fulton, Elaine R Mardis, Richard K Wilson, James R Downing, Douglas R Green, Jinghui Zhang, David W Ellison, Richard J Gilbertson, None, C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma Nature. ,vol. 506, pp. 451- 455 ,(2014) , 10.1038/NATURE13109

Nada Jabado, Mark W Kieran, Adam M Fontebasso, Simon Papillon-Cavanagh, Jeremy Schwartzentruber, Hamid Nikbakht, Noha Gerges, Pierre-Olivier Fiset, Denise Bechet, Damien Faury, Nicolas De Jay, Lori A Ramkissoon, Aoife Corcoran, David T W Jones, Dominik Sturm, Pascal Johann, Tadanori Tomita, Stewart Goldman, Mahmoud Nagib, Anne Bendel, Liliana Goumnerova, Daniel C Bowers, Jeffrey R Leonard, Joshua B Rubin, Tord Alden, Samuel Browd, J Russell Geyer, Sarah Leary, George Jallo, Kenneth Cohen, Nalin Gupta, Michael D Prados, Anne-Sophie Carret, Benjamin Ellezam, Louis Crevier, Almos Klekner, Laszlo Bognar, Peter Hauser, Miklos Garami, John Myseros, Zhifeng Dong, Peter M Siegel, Hayley Malkin, Azra H Ligon, Steffen Albrecht, Stefan M Pfister, Keith L Ligon, Jacek Majewski, Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma Nature Genetics. ,vol. 46, pp. 462- 466 ,(2014) , 10.1038/NG.2950

Veronique Frattini, Vladimir Trifonov, Joseph Minhow Chan, Angelica Castano, Marie Lia, Francesco Abate, Stephen T Keir, Alan X Ji, Pietro Zoppoli, Francesco Niola, Carla Danussi, Igor Dolgalev, Paola Porrati, Serena Pellegatta, Adriana Heguy, Gaurav Gupta, David J Pisapia, Peter Canoll, Jeffrey N Bruce, Roger E McLendon, Hai Yan, Ken Aldape, Gaetano Finocchiaro, Tom Mikkelsen, Gilbert G Privé, Darell D Bigner, Anna Lasorella, Raul Rabadan, Antonio Iavarone, None, The integrated landscape of driver genomic alterations in glioblastoma Nature Genetics. ,vol. 45, pp. 1141- 1149 ,(2013) , 10.1038/NG.2734

Pawel Buczkowicz, Christine Hoeman, Patricia Rakopoulos, Sanja Pajovic, Louis Letourneau, Misko Dzamba, Andrew Morrison, Peter Lewis, Eric Bouffet, Ute Bartels, Jennifer Zuccaro, Sameer Agnihotri, Scott Ryall, Mark Barszczyk, Yevgen Chornenkyy, Mathieu Bourgey, Guillaume Bourque, Alexandre Montpetit, Francisco Cordero, Pedro Castelo-Branco, Joshua Mangerel, Uri Tabori, King Ching Ho, Annie Huang, Kathryn R Taylor, Alan Mackay, Anne E Bendel, Javad Nazarian, Jason R Fangusaro, Matthias A Karajannis, David Zagzag, Nicholas K Foreman, Andrew Donson, Julia V Hegert, Amy Smith, Jennifer Chan, Lucy Lafay-Cousin, Sandra Dunn, Juliette Hukin, Chris Dunham, Katrin Scheinemann, Jean Michaud, Shayna Zelcer, David Ramsay, Jason Cain, Cameron Brennan, Mark M Souweidane, Chris Jones, C David Allis, Michael Brudno, Oren Becher, Cynthia Hawkins, Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations Nature Genetics. ,vol. 46, pp. 451- 456 ,(2014) , 10.1038/NG.2936

D. Singh, J. M. Chan, P. Zoppoli, F. Niola, R. Sullivan, A. Castano, E. M. Liu, J. Reichel, P. Porrati, S. Pellegatta, K. Qiu, Z. Gao, M. Ceccarelli, R. Riccardi, D. J. Brat, A. Guha, K. Aldape, J. G. Golfinos, D. Zagzag, T. Mikkelsen, G. Finocchiaro, A. Lasorella, R. Rabadan, A. Iavarone, Transforming fusions of FGFR and TACC genes in human glioblastoma Science. ,vol. 337, pp. 1231- 1235 ,(2012) , 10.1126/SCIENCE.1220834

Torsten Pietsch, Inken Wohlers, Tobias Goschzik, Verena Dreschmann, Dorota Denkhaus, Evelyn Dörner, Sven Rahmann, Ludger Klein-Hitpass, Supratentorial ependymomas of childhood carry C11orf95–RELA fusions leading to pathological activation of the NF-κB signaling pathway Acta Neuropathologica. ,vol. 127, pp. 609- 611 ,(2014) , 10.1007/S00401-014-1264-4

Khalida Wani, , Terri S. Armstrong, Elizabeth Vera-Bolanos, Aditya Raghunathan, David Ellison, Richard Gilbertson, Brian Vaillant, Stewart Goldman, Roger J. Packer, Maryam Fouladi, Ian Pollack, Tom Mikkelsen, Michael Prados, Antonio Omuro, Riccardo Soffietti, Alicia Ledoux, Charmaine Wilson, Lihong Long, Mark R. Gilbert, Ken Aldape, A prognostic gene expression signature in infratentorial ependymoma Acta Neuropathologica. ,vol. 123, pp. 727- 738 ,(2012) , 10.1007/S00401-012-0941-4

, Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature. ,vol. 455, pp. 1061- 1068 ,(2008) , 10.1038/NATURE07385

Lindsey M Hoffman, Andrew M Donson, Ichiro Nakachi, Andrea M Griesinger, Diane K Birks, Vladimir Amani, Molly S Hemenway, Arthur K Liu, Michael Wang, Todd C Hankinson, Michael H Handler, Nicholas K Foreman, None, Molecular sub-group-specific immunophenotypic changes are associated with outcome in recurrent posterior fossa ependymoma Acta Neuropathologica. ,vol. 127, pp. 731- 745 ,(2014) , 10.1007/S00401-013-1212-8