Expression of Developmentally Regulated Transcription Factors in Merkel Cell Carcinoma

摘要: We have examined a number of developmentally regulated transcription factors for expression in Merkel cells and MCC cell lines demonstrated that their patterns may be prognostic MCC. shown human from adult scalp hair follicle neonatal foreskin epidermal sheets express Brn-3c HATH1. In addition, results demonstrate the novel binding activity complex MNF contains Brn-3c. Moreover, Classic which retain neuroendocrine phenotype, are slow growing culture, grow suspension thought to less aggressive, Brn-2, HATH1 expression, whereas Variant no longer NE markers Brn-2 but lack Further, Type IV as adherent monolayers shorter doubling times, more radiation-resistant higher cloning efficiencies soft agar, all indicative aggressive tumours, reduced or proteins factors.