Toward an understanding of the factors influencing anhydrate-to-hydrate transformation kinetics in aqueous environments

摘要: Approximately one-third of all drugs can form hydrates, and therefore an in-depth understanding the factors affecting anhydrate-to-hydrate transformation kinetics in a variety environments is interest. In this work, real-time analytical methods, Raman spectroscopy optical microscopy, were used to establish representative profiles growth for hydrate formation several drug substances. By comparing contrasting behavior these different hydrates terms their specific properties such as solubility, dissolution rate, rate phase, influence external seeding agitation conditions, increased has been achieved. The overall from anhydrous was found be not only function compound-specific properties, but also strongly affected by surface presence seeds degr...