EFFECT OF PROBIOTIC DAHI (CURD) ON CYTOGENETICAL PROFILE DURING 1,2- DIMETHYLHYDRAZINE INDUCED COLON CARCINOGENESIS IN RATS
作者： R Kumar , PR Sinha , BR Yadav , Arvind Arvind , NK Singh
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摘要: In human, colon cancer is the major health problem worldwide. It arises by a well-defined series of histopathological changes (adenoma-carcinoma sequence), which are paralleled mutations and deletions tumor suppressor genes leading to chromosomal aberrations. Chromosomal aberrations considered be good somatic biomarkers occur with greatest frequency in lymphocytes. The present work was undertaken objective study protective effect probiotic dahi on generation (numerical structural) lymphocytes of1, 2-dimethylhydrazine induced carcinogenesis rats. rats were divided into four groups 1) Normal diet control group; 2) DMH control; 3) (ND) 4) Probiotic (PD) group. Rats injected sacrificed at 50 th week experiment, metaphasic chromosomes prepared from blood incidences studied. normal group, ND group PD incidence 2.0, 15.33, 12.0 4.66% respectively. Administration significantly decreased as compared fed (P< 0.05). findings suggest that exerts its antigenotoxic effects preventing
cabdirect.org参考文章(13)
Henry C. Pitot, Fundamentals of Oncology ,(1978)
Christine Richardson, Maria Jasin, Frequent chromosomal translocations induced by DNA double-strand breaks Nature. ,vol. 405, pp. 697- 700 ,(2000) , 10.1038/35015097
Bin-Bing S. Zhou, Stephen J. Elledge, The DNA damage response: putting checkpoints in perspective Nature. ,vol. 408, pp. 433- 439 ,(2000) , 10.1038/35044005
Kyungjae Myung, Clark Chen, Richard D. Kolodner, Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae Nature. ,vol. 411, pp. 1073- 1076 ,(2001) , 10.1038/35082608
A Bishayee, S Banik, A Mandal, P Marimuthu, M Chatterjee, Vanadium-mediated suppression of diethylnitrosamine-induced chromosomal aberrations in rat hepatocytes and its correlation with induction of hepatic glutathione and glutathione S-transferase. International Journal of Oncology. ,vol. 10, pp. 413- 423 ,(1997) , 10.3892/IJO.10.2.413
Andrew J Pierce, Jeremy M Stark, Felipe D Araujo, Mary Ellen Moynahan, Marianne Berwick, Maria Jasin, Double-strand breaks and tumorigenesis Trends in Cell Biology. ,vol. 11, ,(2001) , 10.1016/S0962-8924(01)02149-3
A. Karlsson, D. Deb-Basu, A. Cherry, S. Turner, J. Ford, D. W. Felsher, Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 9974- 9979 ,(2003) , 10.1073/PNAS.1732638100
Robert S. Weiss, Shuhei Matsuoka, Stephen J. Elledge, Philip Leder, Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Current Biology. ,vol. 12, pp. 73- 77 ,(2002) , 10.1016/S0960-9822(01)00626-1
U Strömberg, S Bonassi, L Hagmar, L E Knudsen, A Brøgger, H Norppa, C Reuterwall, Chromosomal aberrations in lymphocytes predict human cancer: A report from the European study group on cytogenetic biomarkers and health (ESCH) Cancer Research. ,vol. 58, pp. 4117- 4121 ,(1998)
Barry R. Goldin, Sherwood L. Gorbach, Effect of Lactobacillus acidophilus Dietary Supplements on 1,2-Dimethylhydrazine Dihydrochloride-Induced Intestinal Cancer in Rats23 JNCI: Journal of the National Cancer Institute. ,vol. 64, pp. 263- 265 ,(1980) , 10.1093/JNCI/64.2.263