摘要: DNA arrays, first described in 1995, were an immediate success and, for a while, represented the only really large-scale technology available biology. They quickly evolved towards increased complexity, better quality and lower price, thanks largely to industry involvement. In research settings, they at essentially used obtain expression profiles, but their major use today is genome-wide association studies of complex diseases. Clinical applications fall into two categories: profiling tumours predict cancer recurrence orient treatment, genotyping (DNA) studies. The latter can be focused on characterisation pathogenic organisms or, alternatively, examination patient’s assess presence specific mutations as well copy number variations (CNVs) that may have medical significance. These are briefly discussed here then presented more detail following three chapters (expression, variation, respectively).
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