Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response.

摘要: Drinking a sugar solution on an intermittent schedule can promote bingeing and cause signs of dependence while releasing dopamine repeatedly like drug abuse. It is hypothesized that sweet taste alone sufficient for this effect in sucrose rats. On the theory acetylcholine nucleus accumbens plays role satiety, it further purging stomach contents will delay release. Rats with gastric fistulas guide shafts microdialysis were fed 12 h each day. During first hour, open sham-feeding group closed real-feeding group, 10% was only food source. For remaining 11 h, liquid rodent diet available as well to provide balanced diet. In tests during meal days 1, 2 21, extracellular increased at least 30% day both groups. Acetylcholine also meals animals, but not sham feeding. conclusion, increase without fail animals dietary regimen causes dependency. feeding, satiation signal eliminated, drink more. These findings support hypothesis released response when food, satiety greatly reduced by purging; may be relevant bulimia nervosa humans.