5-HT7 receptor subtype as a mediator of the serotonergic regulation of luteinizing hormone release in the zona incerta.

摘要: Abstract 5-Hydroxytryptamine (5-HT) and the 5-HT 1A/7 receptor agonist (+)-8-hydroxy-2-(di- n -propylamino) tetralinHBr (8-OH-DPAT), injected into zona incerta (an area in dorsal hypothalamus) of female rat, inhibit release luteinizing hormone (LH) effects both are blocked by 2/7 antagonist, ritanserin. As 8-OH-DPAT ritanserin have moderate activity at 7 subtype, possibility that this subtype might mediate their has been investigated. Ovariectomised rats were primed with 5 μg oestradiol benzoate followed 48 h 0.5 mg progesterone, which induces an LH surge. 5-Carboxamidotryptamine (5-CT), a potent but non-selective receptors, like 8-OH-DPAT, inhibited surge 1.25 nmol bilaterally incerta. The antagonist selective ( R )-3-(2-(2-(4-methyl-piperidin-1-yl)-pyrrolidine-1-sulfonyl)-phenol (SB-269970-A) μg/side all three agonists when concurrently However, lower (0.2 μg) higher doses (2 SB-269970-A less effective, indicating bell-shaped dose–response curve. was also inhibitory administered systemically (1 mg/kg intraperitoneally (i.p.)). When suppressed benzoate, (0.5 2 did not elevate levels, it is unlikely receptors tonic inhibition on rather involved terminating pre-ovulatory These data demonstrate play role regulation rat brain.