Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?

摘要: According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences mother and her child. The administration of intermittent preventive treatment (IPTp) with sulfadoxine–pyrimethamine (SP) at each antenatal care visit as early 13 weeks gestation until time delivery a strategy that currently recommended by WHO prevention in pregnancy. However, emergence spread resistance SP Africa raise question short-term effectiveness strategy. Dihydroartemisinin–piperaquine 120 mg/960 mg once day 3 consecutive days administered least three times might be an option IPTp. combination 200 mg doxycycline seems good retard artemisinin-based therapy (ACT) improve ACT term preterm births, neonatal morbidity mortality. Contrary preconceived ideas, scientific medical data suggest risk congenital malformations fetus or tooth staining infants whose mothers take hepatotoxicity very low non-existent. Additionally, use first second trimesters leads increase gestational age delivery, decrease number births reduction mortality due beneficial antimicrobial activity against other infections Furthermore, has anti-malarial properties already prophylaxis travellers drugs.