Androgen-induced suppression of autoimmune disease in lacrimal glands of mouse models of Sjögren's syndrome.

摘要: Almost 2,000 years ago, Claudius Galen, the Greek physician and writer, proposed that mental status of an individual may significantly influence one’s susceptibility to disease.1 This postulate serves as historic landmark in rapidly growing field neuroendocrinimmunology, which was established through recognition nervous, endocrine immune systems control each other bidirectional channels communication, employ both similar signals receptors.2–7 At present, over 50 neurotransmitters, hormones secretagogues are known exert a profound impact on cellular, humoral mucosal immunity.2–7 However, exact nature these interactions is extremely dependent upon specific signal, target cell, local microenvironment.8 Thus, depending tissue, neuroendocrine action result stimulation, inhibition, or no effect, expression.8 As additional consideration, antigenic exposure system lead generation numerous lymphocytic cytokines (e.g. lymphokines, neuropeptides, hormones), directly regulate neural function.2–7 In consequence, extensive, triangular interrelationship exists among neural, acts promote homeostasis health.