Bupropion promotes alterations in the spermatogenesis of mice and congenital malformations in the offspring.

摘要: Bupropion hydrochloride (BUP) has been associated with male sexual dysfunction. The aim of this study was to evaluate the effects BUP on reproductive function mice and offspring development. were distributed into group (40 mg kg−1) control (saline). On Day 35 treatment males placed mate females then killed 46 for evaluation function. 18 pregnancy, pregnant congenital malformations in offspring. showed a decrease Johnsen score (Control, 9.354 ± 0.092; BUP, 7.615 ± 0.147), Sertoli 5.623 ± 0.184; 4.215 ± 0.097) Leydig 11.430 ± 0.817; 7.531 ± 0.213) cell counts, testosterone levels 783.5 ± 154.2 ng dL−1; 201.4 ± 54.8 ng dL−1) sperm production 2.852 ± 0.211; 1.988 ± 0.116) increased morphological alterations head 8.134%; 10.423%) tail 4.96%; 16.211%). observed BUP-derived were: kyphosis 0.00%; 5.26%), retroverted rear legs 14.43%; 53.68%), incomplete ossification supraoccipital exoccipital 21.82%; 86.00%) sternum 25.45%; 82.00%). had toxic testicular teratogenic potential.