Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma
作者： Siria Lemma , Peeter Karihtala , Kirsi-Maria Haapasaari , Esa Jantunen , Ylermi Soini
DOI: 10.1111/HIS.12000
关键词:
摘要: Aims: To evaluate the biological roles and prognostic significance of epithelial–mesenchymal transition (EMT)-mediating transcription factors (TFs) Twist, ZEB1 Slug in patients with diffuse large B-cell lymphoma (DLBCL). EMT has been shown to enhance solid tumour metastasis, invasion, proliferation. Methods results: Expression was evaluated immunohistochemically eight samples from reactive lymphoid tissues diagnostic 102 DLBCL treated curative intent R-CHOP-type chemotherapy. expression correlated adverse disease presentation. However, cytoplasmic linked a favourable outcome, whereas nuclear indicated an outcome. Conclusions: This study shows that EMT-like process occurs lymphomas. Of TFs investigated, seems be main one associated clinical presentation outcome. Surprisingly, cytoplasm prognosis. Further studies are needed whether inhibition could serve as therapeutic target.
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