Renin-Angiotensin System

摘要: Over 100 years have passed since the discovery of renin as a “pressor substance” in 1898 by Robert Tigerstedt at Karolinska Institute. The 48-page publication “Niere und Kreislauf” Skandinavisches Archiev fur Physiologie Tiegerstedt and Bergman detailed their meticulous approaches, even including design flow meter to measure blood pressure changes documentation long-lasting pressor effects tachyphylaxis (1). kidney became target studies again 30 some later independently conducted Goldblatt, pathologist who succeeded making dog model renovascular hypertension constricting renal artery with silver clips. This work is based on Goldblatt’s repeated observations that arterial stenosis frequently accompanies hypertension. He also found venous plasma ipsilateral contains vasopressor substance (2). Study renin-angiotensin was given solid base when be peptidase produces peptide angiotensin (a hybrid angiotonin hypertensin), demonstrated Page Braun-Menendez associates late 1930s. Angiotensin I (ANG I) isolated Skeggs et al., structure II II) determined Lentz al. Its synthesis reported Bumpus’ Schwyzer’s groups 1950. discovered two forms steps Ang formation from angiotensinogen way ANG I. Skeggs’ group angiotensin-converting enzyme (ACE). Later, ACE identified kininase Erdos. Erdos an intimate relationship between bradykinin destruction (3).