Prebiotics and resistance to gastrointestinal infections.

摘要: Acute gut disorder is a cause for significant medicinal and economic concern. Certain individual pathogens of the gut, often transmitted in food or water, have ability to severe discomfort. There need manage such conditions more effectively. The route reducing risk intestinal infections through diet remains largely unexplored. Antibiotics are effective at inhibiting pathogens; however, these should not be prescribed absence disease therefore cannot used prophylactically. Moreover, their indiscriminate use has reduced effectiveness. Evidence accumulated suggest that some health-promoting bacteria (probiotics) can elicit multiplicity inhibitory effects against pathogens. Hence, an increase numbers prove repressing pathogen colonisation if/when infectious agents enter gut. As such, fortification indigenous bifidobacteria/lactobacilli by using prebiotics improve protection. number potential mechanisms lactic acid reduce infections. Firstly, metabolic endproducts as acids excreted micro-organisms may lower pH levels below those which able effectively compete. Also, many lactobacilli bifidobacteria species excrete natural antibiotics, broad spectrum activity. Other include improved immune stimulation, competition nutrients blocking adhesion sites Many like type 1 fimbriated Escherichia coli, salmonellae campylobacters utilise oligosaccharide receptor Once established, they then gastroenteritis invasive and/or toxin forming properties. One extrapolation prebiotic concept simulate lumen. 'decoyed' into binding host mucosal interface. combined upon flora anti-adhesive strategies lead towards new dietary interventions safety agents.