The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor.
作者： I. Strehlow , D. Seegert , C. Frick , F.C. Bange , C. Schindler
DOI: 10.1016/S0021-9258(19)85460-1
关键词:
摘要: We have obtained genomic DNA encoding the interferon-gamma (IFN-gamma)-inducible IFP 53/tryptophanyl-tRNA synthetase. Comparison with several different 53 cDNA clones revealed a complex pattern of alternatively spliced 5'-untranslated regions. The interferon-responsive region within promoter was found to contain gamma-interferon activation site (GAS) but not interferon-stimulated response element and bind factor (GAF). GAF.GAS complexes contained IFN-regulated 91-kDa protein. Competition experiments defined GAS boundaries showed that GAF binding could be prevented by an excess IFN-gamma regions other IFN-gamma-inducible genes. thus provide evidence for central role GAS.GAF in gene transcription mediated suggest consensus sequence defining more precisely requirements DNA.
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