Chronic obstructive pulmonary disease induced by exposure to biomass smoke is associated with a Th2 cytokine production profile.

摘要: Smoking and exposure to biomass smoke induce the release of pro-inflammatory mediators activation T helper cells. The resulting inflammatory response contributes development COPD. Clinical heterogeneity exists among COPD patients, particularly between patients with disease associated tobacco smoking (TS-COPD) those exposed (BE-COPD). aim this study was identify whether smokes promotes different Th responses that contribute clinical variability. only included women. frequency Th17 cells in TS-COPD significantly higher than BE-COPD healthy controls (HC). In contrast, had levels Th2 HC. accordance, IL-4 serum concentration TS-COPD. Our data indicates induced by these two irritants may underlie TS- patients.