Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease.

摘要: Alzheimer's disease (AD) is the most common neurodegenerative affliction of elderly, presenting with progressive memory loss and dementia terminating death. There have been significant advances in understanding biology subsequent diagnosis AD; however, furious pace research has not yet translated into a disease-modifying treatment. While scientific inquiry AD largely centered on identifying biological players pathological mechanisms, day-to-day realities patients their caregivers revolve around steady heartbreaking cognitive decline. In past decade, fundamentally transformed by development genetically modified animal models amyloid-driven neurodegeneration. These important vivo only replicate some hallmark pathology disease, such as plaque-like amyloid accumulations astrocytic inflammation, but also impairments relevant to AD. this article, we will provide detailed review behavioral deficits present several transgenic mouse discuss functional changes response experimental treatments.