Dose or ‘LET’ painting – What is optimal in particle therapy of hypoxic tumors?
作者： Eirik Malinen , Åste Søvik
DOI: 10.3109/0284186X.2015.1062540
关键词:
摘要: ABSTRACTBackground. Dose painting is a concept that may increase the tumor control probability (TCP). In particle therapy of hypoxic tumors, it also be beneficial to redistribute linear energy transfer (LET) so oxygen effect minimized; so-called LET painting. The purpose present study was use TCP estimates for comparing dose and tumors.Material methods. Protons, lithium ions carbon were considered. Tumor images tentatively depicting hypoxia used as input. Optimal prescription maps obtained by optimizing under and/or redistribution. TCPs compared those resulting from conventional with no or therapeutic gain at given iso-effect calculated. Treatment adaptation during in response changes spatial distribution considered.Results. Both gave higher therapy, irrespective o...
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