The potential for liquid biopsies in the precision medical treatment of breast cancer.
作者： Victoria A. Forte , Dany K. Barrak , Julie E. Lang , Lily Tung , Mostafa Elhodaky
DOI: 10.28092/J.ISSN.2095-3941.2016.0007
关键词:
摘要: Currently the clinical management of breast cancer relies on relatively few prognostic/predictive markers (estrogen receptor, progesterone HER2), based primary tumor biology. Circulating biomarkers, such as circulating DNA (ctDNA) or cells (CTCs) may enhance our treatment options by focusing very that are direct precursors distant metastatic disease, and probably inherently different than tumor's To shift current paradigm, assessing biology in real time molecularly profiling CTCs ctDNA serve to discover therapeutic targets, detect minimal residual disease predict response treatment. This review serves elucidate detection, characterization, application with goal precision cancer.
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