Serotonin increases interleukin-6 release and decreases tumor necrosis factor release from rat adrenal zona glomerulosa cells in vitro.
作者： Paul K. Ritchie , Heather H. Knight , Marilyn Ashby , Allan M. Judd
DOI: 10.1007/BF02739062
关键词:
摘要: Interleukin-6 (IL-6) and tumor necrosis factor (TNF) are secreted by rat adrenal zona glomerulosa cells. Serotonin increases the release of aldosterone, corti-costerone, cortisol from cortex. Therefore, effects serotonin on IL-6 TNF cells were investigated. Cultures enzymatically prepared cultured for 4–6 d. The then exposed to serum-free RPMl-1640 medium containing vehicle (RPMl alone), serotonin, and/or endotoxin, interleukin-1β, or adrenocorticotrophic hormone (ACTH). Following a 5-h incubation, was removed cells, content this determined with bioassays. (1–1000 nM) increased basal but inhibited these Endotoxin interleukin-1β (IL-1β) potentiated stimulated endotoxin IL-1β, agents. ACTH-stimulated release. had no effect anterior pituitary Because IL-6, TNF, modify aldosterone glucocorticoids stimulatory glucocorticoid may be mediated in part
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