Selected Nonneoplastic Diseases

摘要: Publisher Summary This chapter focuses primarily on nonneoplastic morphological alterations in aging mice. Because only limited published data are available the age-associated incidences of lesions mice, no attempt was made to list all age-associated, present each mouse strain or stock. The discusses important and illustrates incidence patterns that may be seen with specific lesions. Nonneoplasfic, common liver One most findings is presence cellular nuclear pleomorphism mice six months age older. Individual hepatocytes vary both size shape. However, their nuclei often have striking variability. It find two three within a single hepatocyte. mineral deposits brain. These as focal thalamic region usually bilaterally symmetrical; however, they multifocal occur midbrain, cerebellum, cerebrum. They A/J others well. Often, these small appear associated blood vessels; pathogenesis unknown, although increase age.