作者: Shicong Zhu , Zhihua Wang , Zijian Li , Hongling Peng , Yunya Luo
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摘要: Icaritin is an active prenylflavonoid derived from Epimedium genus, a traditional Chinese medicine. has wide range of pharmacological and biological activities, including cardiovascular function improvement, hormone regulation antitumor activity. Here, we investigated the effect icaritin on multiple myeloma (MM) in vitro vivo. inhibited cell growth MM line primary cells. In contrast, had low or no cytotoxic normal hematopoiesis. We also demonstrated that xenograft mouse models, suppressed tumor decreased serum IL-6 IgE levels, but did not show adverse reactions such as body weight loss. The anti-MM activity was mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling. suggest can be further tested clinical trials MM.