Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala.
作者： Kay Jüngling , Thomas Seidenbecher , Ludmila Sosulina , Jörg Lesting , Susan Sangha
DOI: 10.1016/J.NEURON.2008.07.002
关键词:
摘要: A deficient extinction of memory is particularly important in the regime fear, where it limits beneficial outcomes treatments anxiety disorders. Fear thought to involve inhibitory influences prefrontal cortex on amygdala, although detailed synaptic mechanisms remain unknown. Here, we report that neuropeptide S (NPS), a recently discovered transmitter ascending brainstem neurons, evokes anxiolytic effects and facilitates conditioned fear responses when administered into amygdala mice. An NPS receptor antagonist exerts functionally opposing responses, indicating endogenous involved behavior extinction. Cellularly, increases glutamatergic transmission intercalated GABAergic neurons via presynaptic receptors connected principal neurons. These results identify brain, key role for extinction, potential pharmacological avenue treating
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