An Unsettled Promise: The Newborn Piglet Model of Neonatal Acute Respiratory Distress Syndrome (NARDS). Physiologic Data and Systematic Review.

摘要: Despite great advances in mechanical ventilation and surfactant administration for the newborn infant with life-threatening respiratory failure no specific therapies are currently established to tackle major pro-inflammatory pathways. The susceptibility of neonatal acute distress syndrome (NARDS) exogenous is linked a suppression most immunologic responses by innate immune system, however, additional corticosteroids applied any severe pediatric lung disease inflammatory background do not reduce morbidity or mortality may even cause harm. Thus, piglet model injury serves as an excellent study preferred animal reasons availability, body size, similarities porcine human lung, robustness, costs. In addition, toll-like receptor 4, existence intraalveolar macrophages, sensitivity lipopolysaccharide, production nitric oxide make indispensable anti-inflammatory research. Here we present physiologic data piglets from three trials involving secondary repeated airway lavage (and others), ventilation, intervention via intratracheal route using carrier substance. many organ systems piglet-but preference on lung-are presented here differentiating between baseline uninjured piglet, impact various parameters (24 h), follow up after 72 h ventilation. Data control group groups listed separately combined. A systematic review meconium aspiration finally presented. While studies assessed scores, leukocyte infiltration, protein/cytokine concentrations bronchoalveolar fluid, approach upstream pathways system still fledgling stages. For sake infants NARDS unsettled promise offering options conquer physiology/immunology establish potent treatment modalities.