Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival

摘要: The paired-box (PAX) genes encode a family of nine well-characterized transcription factors, with important roles in development and disease. Although PAX are primarily expressed the embryo, constitutive expression promotes tissue hyperplasia. Rare tumor-specific mutations implicate an oncogenic role, persistent characterizes several tumors. Yet, cancer-wide analysis gene to investigate general role for has not been performed. We analysed pattern requirement panel common cancer cell lines. Very frequent was identified tumor lines, including lymphoma, breast, ovarian, lung, colon cancer. In addition, PAX2 frequently 406 primary tissues. Apoptosis rapidly induced ovarian bladder lines following RNA interference silence expression, despite concomitant TP53 and/or HRAS mutations. These data suggest that cancer, endogenous is required growth survival cells.