Degenerative and Vascular Fluent Aphasia: Looking for Differences.

摘要: Objective To investigate whether the characteristics of language disorders degenerative and vascular aphasias depend on underlying neuropathology. Methods Logopenic variant/mixed primary progressive aphasics (lvmPPA; n=18) poststroke fluent (PSA; n=11) underwent a neuropsychological examination an assessment macro- microlinguistic aspects language. A principal component analysis cluster applying two-group solution were performed scores obtained from examination. Results Global cognition, lexical-semantic, morphosyntactic components, two components loading macrolinguistic variables, extracted by analysis. first 18 participants (14 lvmPPA 4 PSA) second 11 (4 7 identified. Participants in significantly more impaired than those global components. Macrolinguistic did not differentiate clusters. showed bilateral cortical thinning (greater left), whereas atrophy only left. with PSA both clusters lesions encompassing posterior left perisylvian regions. Underestimation severity leukoencephalopathy damage interhemispheric connectivity might be responsible for inclusion individuals cluster, despite unilateral lesion. Conclusions Lesion localization is main factor that determines aphasic deficits. Etiology indirectly acts through different sensitivity brain regions to various pathologies.