Molekulargenetische und physiologische Untersuchungen zur Vererbung des Erbdefektes Hernia inguinalis/scrotalis beim Schwein

摘要: Hernia inguinalis/scrotalis (i/s) in pigs are known as congenital defects which occur with a frequency of 1-3% and heritability h2 = 0.02 to 0.86 German pig breeds cause enormous economic losses.Therefore, the elucidation mode inheritance development DNA based tests crucial scientific concern.At Institute Veterinary Medicine (IVM) studies genetic basis take place within national research project Entwicklung von Techniken und Methoden zur Kartierung Defektgenen beim Schwein .In present study, we determined calcium contents peritoneal tissue samples Processus vaginalis piglets were associated (i/s). Our results showed significant difference content collected from reproduction tract between obtained affected animals compared those normal healthy pigs.Due these - additionally on genome wide linkage scan, was carried out at IVM mapped functional candidate genes porcine chromosomes (Sus scrofa chromosome, SSC) 3, 6, 7 15 considered be positional candidates. These genes, supposed play an important role homeostasis apoptotic cascade. Furthermore, polymorphic microsatellites detected by target oligonucleotide mediated microsatellite identification (TOMMI) tested population families.