Channelrhodopsin-2 is a leaky proton pump

作者: K. Feldbauer , D. Zimmermann , V. Pintschovius , J. Spitz , C. Bamann

DOI: 10.1073/PNAS.0905852106

关键词:

摘要: … Whereas this so-called optogenetic approach has found broad application in the field of neuroscience (7, 8), little is known about the basic properties of the light-gated channel. A major …

参考文章(21)
Louis J. DeFelice, Introduction to membrane noise ,(1981)
Wei Zhang, Wooping Ge, Zuoren Wang, A toolbox for light control of Drosophila behaviors through Channelrhodopsin 2-mediated photoactivation of targeted neurons. European Journal of Neuroscience. ,vol. 26, pp. 2405- 2416 ,(2007) , 10.1111/J.1460-9568.2007.05862.X
Eglof Ritter, Katja Stehfest, Andre Berndt, Peter Hegemann, Franz J. Bartl, Monitoring Light-induced Structural Changes of Channelrhodopsin-2 by UV-visible and Fourier Transform Infrared Spectroscopy Journal of Biological Chemistry. ,vol. 283, pp. 35033- 35041 ,(2008) , 10.1074/JBC.M806353200
Bertil Hille, Wolfgang Schwarz, K channels in excitable cells as multi-ion pores Brain Research Bulletin. ,vol. 4, pp. 159- 162 ,(1979) , 10.1016/0361-9230(79)90079-0
E. Bamberg, H. -J. Apell, N. A. Dencher, W. Sperling, H. Stieve, P. Läuger, Photocurrents generated by bacteriorhodopsin on planar bilayer membranes Biophysics of Structure and Mechanism. ,vol. 5, pp. 277- 292 ,(1979) , 10.1007/BF02426663
P. Hegemann, L. T. Landmesser, S. Herlitze, X. Li, D. V. Gutierrez, M. G. Hanson, J. Han, M. D. Mark, H. Chiel, Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 17816- 17821 ,(2005) , 10.1073/PNAS.0509030102
Oliver P. Ernst, Pedro A. Sánchez Murcia, Peter Daldrop, Satoshi P. Tsunoda, Suneel Kateriya, Peter Hegemann, Photoactivation of channelrhodopsin. Journal of Biological Chemistry. ,vol. 283, pp. 1637- 1643 ,(2008) , 10.1074/JBC.M708039200
The Photoreceptor Current of the Green Alga Chlamydomonas Philosophical Transactions of the Royal Society B. ,vol. 338, pp. 39- 52 ,(1992) , 10.1098/RSTB.1992.0127
André Berndt, Ofer Yizhar, Lisa A Gunaydin, Peter Hegemann, Karl Deisseroth, Bi-stable neural state switches. Nature Neuroscience. ,vol. 12, pp. 229- 234 ,(2009) , 10.1038/NN.2247
Benjamin R Arenkiel, Joao Peca, Ian G Davison, Catia Feliciano, Karl Deisseroth, George J Augustine, Michael D Ehlers, Guoping Feng, None, In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2 Neuron. ,vol. 54, pp. 205- 218 ,(2007) , 10.1016/J.NEURON.2007.03.005